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Nano Clairvoyance Blog : A peek into Nanomedicine Research


Updated: Jan 4, 2021

“ We have reported an implantable device based on the superparamagnetic Graphene Oxide doxorubicin (SPGO DOX) nanocomposite in a nanofiber matrix is used as a multimodal breast cancer treatment device for cancer therapy as well as the supportive biodegradable scaffolds for adipose tissue substitute for breast reconstruction.”

Cancer is one of the most deadly diseases in the world. Among females, breast cancer is very frequent and accounts for 15% of all cancer deaths in them and 25% of all cancer cases. The main treatment include tumor resection surgeries along with postoperative radiotherapy and chemotherapy (CT). The survival rates of breast cancer patients are determined by the rate of local regional recurrence (LRR) of the tumour caused by the residual tumour cells even after the surgery.

Researchers including me at the Chonbuk National University, South Korea have developed an implantable anticancer device (IAD) amenable to eradicate local regional breast cancer recurrence (LRR) as well as to enhance the breast reconstruction during/after therapy. The IAD is fabricated by incorporating the superparamagnetic graphene oxide doxorubicin (SPGO DOX) nanocomposite of size ~200 nm in a nanofiber matrix to enable the sustained and tumor specific anticancer drug release over 60 days in vitro with a minimum initial burst release and the repeated hyperthermic capability in an alternating magnetic field to ensure the synergistic inhibition of LRR. The IAD also enrich the reconstruction of poor breast cosmesis resulted from the surgical treatment by supporting the lipofilling of the surgical residual cavity to induce the adipogenic process. Moreover, the non-invasive monitoring capability of IAD through magnetic resonance imaging augments the effectiveness of the IAD for the Post surgical treatment.

Journal Reference: Arathyram Ramachandra Kurup Sasikala, Afeesh Rajan Unnithan, Chan Hee Park, Cheol Sang Kim, Multifaceted Implantable Anticancer Device for Potential Postsurgical Breast Cancer Treatment: A Single Platform for Synergistic Inhibition of Local Regional Breast Cancer Recurrence, Surveillance and Healthy Breast Reconstruction, Advanced Functional Materials, 28, 1704793, 2018

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